Cassette Dosing Studies. Cassette dosing, alternatively called N-in-1 dosing, is an attractive procedure for higher-throughput screening in drug discovery to rapidly screen large numbers of candidate compounds for assessing their pharmacokinetic properties, while minimizing the number of animals.

mobile staphylococcal cassette chromosome (SCC) that contains the mecA gene complex (SCC mec) (3). Until now, 5 major types of SCC mec element have been characterized and studied (3–5). However, longitudinal studies of SCCmec elements in nosocomial MRSA isolates in a hos-pital have seldom been reported (6). We analyzed SCC mec.

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Sep 01,  · Cassette dosing was proposed in the late s when Berman et al. 6 evaluated the correlation between cassette and discrete dosing in dogs for five compounds and demonstrated that comparable PK parameters are obtained with the two study designs. Advances in mass spectrometric technology, such as the advent of multiple reaction monitoring and Cited by:

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